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Provedor de dados:  ArchiMer
País:  France
Título:  Marine green macroalgae: a source of natural compounds with mineralogenic and antioxidant activities
Autores:  Surget, Gwladys
Roberto, Vania P.
Le Lann, Klervi
Mira, Sara
Guerard, Fabienne
Laize, Vincent
Poupart, Nathalie
Leonor Cancela, M.
Stiger-pouvreau, Valerie
Data:  2017-02
Ano:  2017
Palavras-chave:  Ulvophyceae
Phenolic compounds
Antioxidant activity
Mineralogenic activity
Proliferative activity
Resumo:  Marine macroalgae represent a valuable natural resource for bioactive phytochemicals with promising applications in therapeutics, although they remain largely under-exploited. In this work, the potential of two marine green macroalgae (Cladophora rupestris and Codium fragile) as a source of bioactive phenolic compounds was explored, and antioxidant, mineralogenic, and osteogenic activities were evaluated. For each species, a crude hydroalcoholic extract (CE) was prepared by solid/liquid extraction and fractionated by liquid/liquid purification into an ethyl acetate fraction (EAF) enriched in phenolic compounds and an aqueous fraction (AF). Antioxidant activity, assessed through radical scavenging activity and reducing power assay, was increased in EAF fraction of both species and closely related to the phenolic content in each fraction. Mineralogenic activity, assessed through extracellular matrix mineralization of a fish bone-derived cell line, was induced by EAF fractions (up to 600 % for C. rupestris EAF). Quantitative analysis of operculum formation in zebrafish larvae stained with alizarin red S further confirmed the osteogenic potential of EAF fractions in vivo, with an increase of more than 1.5-fold for both C. fragile and C. rupestris fractions, similar to vitamin D (control). Our results demonstrated a positive correlation between phenolic fractions and biological activity, suggesting that phenolic compounds extracted from marine green macroalgae may represent promising molecules toward therapeutic applications in the field of bone biology.
Tipo:  Text
Idioma:  Inglês

Editor:  Springer
Relação:  info:eu-repo/grantAgreement/EC/FP7/249552/EU//SEAS ERA
Formato:  application/pdf
Fonte:  Journal Of Applied Phycology (0921-8971) (Springer), 2017-02 , Vol. 29 , N. 1 , P. 575-584
Direitos:  Springer Science+Business Media Dordrecht 2016


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