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Provedor de dados:  5
País:  France
Título:  Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis
Autores:  El-demerdash, Amr
Moriou, Celine
Toullec, Jordan
Besson, Marc
Soulet, Stephanie
Schmitt, Nelly
Petek, Sylvain
Lecchini, David
Debitus, Cecile
Al-mourabit, Ali
Data:  2018-05
Ano:  2018
Palavras-chave:  Brominated tyrosine alkaloids
Suberea ianthelliformis
Acetylcholinesterase inhibition
Resumo:  Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively.
Tipo:  Text
Idioma:  Inglês

Editor:  Mdpi
Relação:  info:eu-repo/grantAgreement/EC/FP7/634674/EU//TASCMAR
Formato:  application/pdf
Fonte:  Marine Drugs (1660-3397) (Mdpi), 2018-05 , Vol. 16 , N. 5 , P. 146 (16p.)
Direitos:  2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (


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