| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Genomic diversity and evolution of the lyssaviruses.
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| Autores: |
Delmas, Olivier
Holmes, Edward
Talbi, Chiraz
Dacheux, Laurent
Bouchier, Christiane
Larrous, Florence
Bourhy, Hervé
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| Data: |
2008
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| Ano: |
2008
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| Resumo: |
Lyssaviruses are RNA viruses with single-strand, negative-sense genomes responsible for rabies-like diseases in mammals. To date, genomic and evolutionary studies have most often utilized partial genome sequences, particularly of the nucleoprotein and glycoprotein genes, with little consideration of genome-scale evolution. Herein, we report the first genomic and evolutionary analysis using complete genome sequences of all recognised lyssavirus genotypes, including 14 new complete genomes of field isolates from 6 genotypes and one genotype that is completely sequenced for the first time. In doing so we significantly increase the extent of genome sequence data available for these important viruses. Our analysis of these genome sequence data reveals that all lyssaviruses have the same genomic organization. A phylogenetic analysis reveals strong geographical structuring, with the greatest genetic diversity in Africa, and an independent origin for the two known genotypes that infect European bats. We also suggest that multiple genotypes may exist within the diversity of viruses currently classified as ‘Lagos Bat’. In sum, we show that rigorous phylogenetic techniques based on full length genome sequence provide the best discriminatory power for genotype classification within the lyssaviruses.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
http://archimer.ifremer.fr/doc/00139/24994/23092.pdf
DOI:10.1371/journal.pone.0002057
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| Editor: |
Public Library Science
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| Relação: |
http://archimer.ifremer.fr/doc/00139/24994/
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| Formato: |
application/pdf
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| Fonte: |
PLOS One (1932-6203) (Public Library Science), 2008 , Vol. 3 , N. 4 , P. 1-6
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| Direitos: |
2008 Delmas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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