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Provedor de dados:  5
País:  France
Título:  Chronic dietary exposure of zebrafish to PAH mixtures results in carcinogenic but not genotoxic effects
Autores:  Larcher, Thibaut
Perrichon, Prescilla
Vignet, Caroline
Ledevin, Mireille
Le Menach, Karyn
Lyphout, Laura
Landi, Laure
Clerandeau, Christelle
Lebihanic, F.
Menard, Dominique
Burgeot, Thierry
Budzinski, Helene
Akcha, Farida
Cachot, J.
Cousin, Xavier
Data:  2014-12
Ano:  2014
Palavras-chave:  Polycyclic aromatic hydrocarbon
Zebrafish
Carcinogenesis
Genotoxicity
Neoplasia
Carcinoma
Toxicological pathology
Resumo:  Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants that can be present at high levels as mixtures in polluted aquatic environments. Many PAHs are potent mutagens and several are well-known carcinogens. Despite numerous studies on individual compounds, little is known about the toxicity of PAHs mixtures that are encountered in environmental situations. In the present work, zebrafish were continuously fed from 5 days post-fertilisation to 14 months post-fertilisation (mpf) with a diet spiked with fractions of either pyrolytic (PY), petrogenic light oil (LO), or petrogenic heavy oil (HO) origin at three concentrations. A decrease in survival was identified after 3 mpf in fish fed with the highest concentration of HO or LO, but not for PY. All PAH fractions caused preneoplastic and neoplastic disorders in long-term-exposed animals. Target tissues were almost exclusively of epithelial origin, with the bile duct epithelium being the most susceptible to chronic exposure to all PAH fractions, and with germ cells being the second most responsive cells. Significantly higher incidences of neoplasms were observed with increasing PAH concentration and exposure duration. The most severe carcinogenic effects were induced by dietary exposure to HO compared to exposure to LO or PY (45, 30 and 7 %, respectively, after 9 to 10 months of exposure to an intermediate concentration of PAHs). In contrast, earliest carcinogenic effects were detected as soon as 3 mpf after exposure to LO, including the lowest concentration, or to PY. PAH bioactivation and genotoxicity in blood was assessed by ethoxyresorufin-O-deethylase activity quantification and comet and micronuclei assays, respectively, but none of these were positive. Chronic dietary exposure of zebrafish to PAH mixtures results in carcinogenotoxic events that impair survival and physiology of exposed fish.
Tipo:  Text
Idioma:  Inglês
Identificador:  https://archimer.ifremer.fr/doc/00242/35329/34108.pdf

DOI:10.1007/s11356-014-2923-7

https://archimer.ifremer.fr/doc/00242/35329/
Editor:  Springer Heidelberg
Formato:  application/pdf
Fonte:  Environmental Science And Pollution Research (0944-1344) (Springer Heidelberg), 2014-12 , Vol. 21 , N. 24 , P. 13833-13849
Direitos:  Springer-Verlag Berlin Heidelberg 2014

info:eu-repo/semantics/openAccess

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