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Provedor de dados:  5
País:  France
Título:  Environmental concentrations of benz[a]anthracene induce developmental defects and DNA damage and impair photomotor response in Japanese medaka larvae
Autores:  Le Bihanic, Florane
Sommard, Vivien
De Lansalut, Perrine
Pichon, Anaïk
Grasset, Julie
Berrada, Saadia
Budzinski, Helene
Cousin, Xavier
Morin, Benedicte
Cachot, Jerome
Data:  2015-03
Ano:  2015
Palavras-chave:  Benz[a]anthracene
Spiked sediment
DNA damage
Swimming behavior
In vivo EROD activity
Resumo:  Benz[a]anthracene (BaA) is a ubiquitous polycyclic aromatic hydrocarbon found in numerous aquatic ecosystems. However, ecotoxicological data in aquatic organisms are scarce. To remedy this lack of data, Japanese medaka (Oryzias latipes) embryos were exposed to BaA and toxic effects were investigated at multiple toxicological endpoints. Japanese medaka embryos were incubated onto BaA-spiked artificial sediment for 9 days at low or moderate environmental concentrations ranging from 0.9 to 12 µg g−1 dw. BaA-exposed embryos exhibited significant tachycardia. BaA exposure was also shown to increase CYP1A activity in the hepato-biliary tissue as well as craniofacial deformities and DNA damage in pro-larvae. The photomotor response of BaA-exposed larvae was reduced in comparison to the control group. According to this set of tests, the lowest tested and observed effect concentration (LOEC) for Japanese medaka early life stages was equivalent to 0.92 µg g−1 dw of BaA. This concentration fall into the range of concentrations frequently encountered in sediments of polluted aquatic ecosystems. Taking into consideration these results, BaA represents a threat for fish early life stages in particular those developing onto or into contaminated sediments.
Tipo:  Text
Idioma:  Inglês

Editor:  Academic Press Inc Elsevier Science
Formato:  application/pdf
Fonte:  Ecotoxicology And Environmental Safety (0147-6513) (Academic Press Inc Elsevier Science), 2015-03 , Vol. 113 , P. 321-328
Direitos:  2014 Elsevier Inc. All rights reserved.


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