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Provedor de dados:  5
País:  France
Título:  Dietary exposure of juvenile common sole (Solea solea L.) to polybrominated diphenyl ethers (PBDEs): Part 2. Formation, bioaccumulation and elimination of hydroxylated metabolites
Autores:  Munschy, Catherine
Moisan, Karine
Tixier, Celine
Pacepavicius, G.
Alaee, M.
Data:  2010-12
Ano:  2010
Palavras-chave:  Marine flatfish
Hydroxylated metabolites
Resumo:  The uptake, elimination and transformation of six PBDE congeners (BDE-28, -47, -99, -100, -153, -209) were studied in juvenile common sole (Solea solea L) exposed to spiked contaminated food over a three-month period, and then depurated over a five-month period. Methoxylated (MeO-) and hydroxylated (OH-) PBDEs were determined in fish plasma exposed to PBDEs and compared to those obtained in control fish. While all MeO- and some OH- congeners identified in fish plasma were found to originate from non-metabolic sources, several OH- congeners, i.e., OH-tetraBDEs and OH-pentaBDEs, were found to originate from fish metabolism. Among these, 4 '-OH-BDE-49 was identified as a BDE-47 metabolite. Congener 4 '-OH-BDE-101, identified here for the first time, may be the result of BDE-99 metabolic transformation. Our results unequivocally showed that PBDEs are metabolised in juvenile sole via the formation of OH- metabolites. However, this was not a major biotransformation route compared to biotransformation through debromination. (C) 2010 Elsevier Ltd. All rights reserved.
Tipo:  Text
Idioma:  Inglês

Editor:  Elsevier Sci Ltd
Formato:  application/pdf
Fonte:  Environmental Pollution (0269-7491) (Elsevier Sci Ltd), 2010-12 , Vol. 158 , N. 12 , P. 3527-3533
Direitos:  2010 Elsevier Ltd All rights reserved.

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