| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Biocompatibility, osteointegration, osteoconduction, and biodegradation of a hydroxyapatite-polyhydroxybutyrate composite
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| Autores: |
Reis,Emily Correna Carlo
Borges,Andréa Pacheco Batista
Fonseca,Cláudio César
Martinez,Mastoby Miguel Martinez
Eleotério,Renato Barros
Morato,Gláucia Oliveira
Oliveira,Paulo Miranda
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| Data: |
2010-08-01
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| Ano: |
2010
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| Palavras-chave: |
Biomaterials
Bone
Biocompatibility
Biodegradation
Hydroxyapatite-polyhydroxybutyrate composite
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| Resumo: |
In this work, biocompatibility, osteointegration, osteoconductivity, and biodegradation of a hydroxyapatite polyhydroxybutyrate new composite were evaluated. The composite was implanted in rabbits' bone defects and clinical, radiographic, histological, and histomorphometric data of these animals were compared with those of unfilled defects on the days 8th, 45th, and 90th after surgery. No significant differences existed between the groups for the evaluated clinical parameters. Radiographs showed bone-composite direct contact. Bone formed within the defect, interface and inside the composite. Significant differences were found between the bone and connective tissues percentage within the defect at all dates and at the interface on the 45th day, bone tissue prevailing. Composite's biodegradation signs were evident: giant cells on the surface of composite fragments separated from the original block in the absence of inflammatory infiltrate. These data supported that such composite was biocompatible, biodegradable, osteoconductive and integrate to bone.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000400010
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132010000400010
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.53 n.4 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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