| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Methotrexate inhibits integrin adhesion molecules in the mouse model of pleurisy induced by carrageenan
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| Autores: |
Dalmarco,Eduardo Monguilhott
Fröde,Tânia Silvia
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| Data: |
2007-09-01
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| Ano: |
2007
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| Palavras-chave: |
Methotrexate
CD11a/CD18 adhesion molecules
Leukocyte migration
Pleurisy
Mice
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| Resumo: |
The aim of this work was to analyze the effect of methotrexate (MTX) upon leukocyte migration and expression of adhesion molecules CD11a/CD18 in the lung, 4 and 48 h after inflammation induction by carrageenan in mice. The results showed that MTX significantly decreased leukocyte influx and CD11a expression in the lung at 4 and 48 h of pleurisy (P < 0.01). MTX also inhibited CD18 expression at 4 h but not 48 h of pleurisy (P < 0.01). These results proved that MTX at the studied doses had important anti-inflammatory properties, acting primarily on leukocyte migration from the pleural cavity to the lung via inhibition of CD11a/CD18 expression in the mouse model of inflammation.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000500005
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132007000500005
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.50 n.5 2007
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| Direitos: |
info:eu-repo/semantics/openAccess
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