| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Morphological alterations and G0/G1 cell cycle arrest induced by curcumin in human SK-MEL-37 melanoma cells
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| Autores: |
Carneiro,Marcella Lemos Brettas
Porfírio,Elaine Paulucio
Otake,Andréia Hanada
Chammas,Roger
Báo,Sônia Nair
Guillo,Lidia Andreu
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| Data: |
2010-04-01
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| Ano: |
2010
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| Palavras-chave: |
Curcumin
Melanoma cells
Apoptosis
Cell cycle
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| Resumo: |
The aim of this work was to study the effect of curcumin on cell cycle in the human SK-MEL-37 melanoma cell line. In addition, morphological and structural analyses were also performed. Flow cytometric analysis showed a G0/G1 arrest at 5 µM after 24 h exposure and a concentration-dependent increase in the proportion of sub-G0 hypodiploid cells. Typical apoptotic events were also observed by the fluorescence microscopy, transmission and scanning electronic microscopy. Loss of mitochondrial membrane potential was not detected. Results suggested that curcumin could arrest human melanoma cells at G0/G1 phase and induce a mitochondrial-independent apoptotic pathway.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000200013
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132010000200013
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.53 n.2 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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