| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Antibody conjugate radioimmunotherapy of superficial bladder cancer
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| Autores: |
Perkins,Alan
Hopper,Melanie
Murray,Andrea
Frier,Malcolm
Bishop,Mike
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| Data: |
2002-09-01
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| Ano: |
2002
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| Palavras-chave: |
Antibody
Radioimmunotherapy
Bladder cancer
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| Resumo: |
The administration of antibody conjugates for cancer therapy is now proving to be of clinical value. We are currently undertaking a programme of clinical studies using the monoclonal antibody C595 (IgG3) which reacts with the MUC1 glycoprotein antigen that is aberrantly expressed in a high proportion of bladder tumours. Radioimmunoconjugates of the C595 antibody have been produced with high radiolabelling efficiency and immunoreactivity using Tc-99m and In-111 for diagnostic imaging, and disease staging and the cytotoxic radionuclides Cu-67 and Re-188 for therapy of superficial bladder cancer. A Phase I/II therapeutic trail involving the intravesical administration of antibody directly into the bladder has now begun.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500012
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132002000500012
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.45 n.spe 2002
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| Direitos: |
info:eu-repo/semantics/openAccess
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