| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Aqueous extract of Huang-lian induces apoptosis in lung cancer cells via P53- mediated mitochondrial apoptosis
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| Autores: |
Zhu,Deying
Lin,Zhe
Li,Zhenzhong
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| Data: |
2015-06-01
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| Ano: |
2015
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| Palavras-chave: |
Huang-lian
Aqueous extract
Apoptosis
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| Resumo: |
The current study was designed to evaluate the activity of the aqueous extract of Huang-lian, and the main apoptosis pathway induced by the extracts of Huang-lian was detected on lung cancer. Antiproliferactive activity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and TUNEL methods against human lung cancer cells (A549). Huang-lian regulated the Bcl-2 family protein-mediated mitochondrial pathway via p53 and was detected by western blot. It increased the activation of caspase-3 and caspase-3 cleavage increased as the time increased. These results suggested that Huang-lianregulated the Bcl-2 family protein-mediated mitochondrial via p53 pathway, suggesting that Huang-lian should be further investigation as a natural agent for treating and preventing cancer.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000300353
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-8913201500070
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.58 n.3 2015
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| Direitos: |
info:eu-repo/semantics/openAccess
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