| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Frequency of class I anti-HLA alloantibodies in patients infected by HIV-1
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| Autores: |
Leite,Elza Regina Manzolli
Lima,Oswaldo Luiz Luz
Leite,Fábio Renato Manzolli
Costa,Paulo Inácio da
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| Data: |
2010-02-01
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| Ano: |
2010
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| Palavras-chave: |
AIDS
HIV
HLA antigens
Alloantibodies
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| Resumo: |
The aim of this study was to evaluate the presence of class I anti-HLA alloantibodies in patients infected by HIV-1 and relate it with the different clinical courses of the disease. Blood samples were collected in EDTA tubes from 145 individuals. HIV-1 infection was confirmed by ELISA test. The presence of class I anti-HLA alloantibodies and HLA allele's were determined. Clinical evolution was set as fast (<1 year between diagnostic and death), moderate (1-3 years) or slow (>3 years). Class I anti-HLA alloantibodies presence was lower in healthy individuals than in those infected by HIV-1 (4.2% against 32.4%). However, an equal distribution of these alloantibodies was found among the individuals infected, independent on the clinical evolution. Thus, class I anti-HLA alloantibodies was not a determinant factor for patient worsening.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000100012
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132010000100012
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.53 n.1 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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