| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Intrauterine sexual differentiation: biosyntesis and action of sexual steroid hormones
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| Autores: |
Santos,Amilton Cesar dos
Viana,Diego Carvalho
Oliveira,Gleidson Benevides de
Lobo,Luis Miguel
Assis-Neto,Antônio Chaves
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| Data: |
2015-06-01
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| Ano: |
2015
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| Palavras-chave: |
P450 cytochrome
Sexual differentiation
Müllerian ducts
Wolff duct
Steroidogenesis
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| Resumo: |
The objective of this review was to describe sexual differentiation events in mammals, relating them to biosynthesis of sexual steroid hormones and their mechanisms of action. Cholesterol is the precursor of sexual steroid hormone biosynthesis via action of several enzymes converting these hormones. Progestagens hormones serve as substrate for the production of androgens, which in turn serve as substrate for estrogen hormones. These hormones are responsible for sexual differentiation and reproductive cycles of mammals. Sexual differentiation process comprises determining the sexual chromosomes XX or XY + SRY and other genes linked to them, differentiation of gonads in testis or ovary, differentiation of internal and external male or female genital organs from undifferentiated anatomical structures present in the embryo, which is dependent on the presence or absence of testes and the production of anti-Müllerian hormone and testosterone; and secondary sexual differentiation, which is the response of various tissues to hormones produced by the gonads, interacting with genes linked to sexual chromosomes to increase or decrease the differences in sexual phenotype. However, some differences between the sexes and some anomalies of sexual differentiation are not explained only by these sexual hormonal effects, but also by the effect of genes encoded in sexual chromosomes.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000300395
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-8913201500479
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.58 n.3 2015
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| Direitos: |
info:eu-repo/semantics/openAccess
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