| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Isolation, Characterization, Antioxidant, Antimicrobial and Cytotoxic Effect of Marine Actinomycete, Streptomyces Carpaticus MK-01, against Fish Pathogens
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| Autores: |
Subramanian,Dharaneedharan
Kim,Min-Sun
Kim,Dong-Hwi
Heo,Moon-Soo
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| Data: |
2017-01-01
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| Ano: |
2017
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| Palavras-chave: |
Actinomycete
Streptomyces carpaticus MK-01
Antioxidant
Cytotoxicity
Jeju Island
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| Resumo: |
ABSTRACT Present study aim to evaluate the antimicrobial, antioxidant and cytotoxic potential of crude extract of Marine Streptomyces carpaticus MK-01 isolated from seawater collected from Daejeong-cost of Jeju Island. About 24 actinomycetes strains were isolated and subjected to morphological and molecular analysis that confirmed the isolate as S. carpaticus MK-01. Crude ethyl acetate extract of MK-01 strain showed extensive antibacterial activity against Gram-positive fish pathogenic bacteria namely Streptococcus iniae and S. parauberis with a maximum zone of inhibition (0.92±0.03mm) was recorded against S. parauberis at the minimum extract concentration (3.12µg/ml). The MK-01 ethyl acetate extract shows dose dependant significant increase in antioxidant activity. The 50% cytotoxic concentration (CC50) of MK-01 ethyl acetate extract was attained at 53.71 μg/ml and the effective concentration 50 (EC50) against virus-infected Epithelioma papulosum cyprini cell lines was 8.72 μg/ml of S. carpaticus MK-01 crude ethyl acetate extract.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100437
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/1678-4324-2017160539
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.60 2017
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| Direitos: |
info:eu-repo/semantics/openAccess
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