| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Neonatally induced diabetes: liver glycogen storage in pregnant rats
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| Autores: |
Iessi,Isabela Lovizutto
Bueno,Aline
Sinzato,Yuri Karen
Spada,Ana Paula Machado
Rudge,Marilza Vieira Cunha
Heubel,Maricê Thereza Correa Domingues
Damasceno,Débora Cristina
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| Data: |
2012-04-01
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| Ano: |
2012
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| Palavras-chave: |
Pregnancy
Rat
Hyperglycemia
Glycogen storage liver
Mild diabetes
Hyperglycemia
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| Resumo: |
The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200010
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132012000200010
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.55 n.2 2012
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| Direitos: |
info:eu-repo/semantics/openAccess
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