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Provedor de dados:  BABT
País:  Brazil
Título:  Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment
Autores:  Patel,Dhaval J
Patel,Jayvadan K
Data:  2013-04-01
Ano:  2013
Palavras-chave:  Famotidine
Box-Behnken design
Peptic ulcer
Resumo:  The present study was performed to design and evaluate the famotidine loaded mucoadhesive nanosuspension for aspirin induced ulcer. A 3-factor, 3-level Box-Behnken design was applied to study the effects of amount of the beads (X1), PVPK-30(X2) and Tween-80 (X3) on the particle size (Y1), and cumulative percentage drug released after 1h (Y2). The optimization was performed using the desirability function and contour plots. The scanning electron microscopy (SEM) showed the nanoparticles as spherical in shape. The differential scanning calorimetry (DSC) analysis indicated that there was substantial crystallinity change in the nanoparticle compared with the pure drug. Ex-vivo mucoadhesion study showed that famotidine mucoadhesive nanoparticles possessed higher mucoadhesion than the famotidine nanoparticles. The in vivo studies on aspirin-induced rats indicated the lowering in ulcer index for famotidine mucoadhesive nanoparticles was 0.46+0.011, which was significantly better than the effect of traditional famotidine suspension (0.66+0.035). Famotidine mucoadhesive nanosuspension could be prepared using the media milling technique and allowing significant reduction in ulcer index compared to famotidine suspension.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Instituto de Tecnologia do Paraná - Tecpar
Relação:  10.1590/S1516-89132013000200007
Formato:  text/html
Fonte:  Brazilian Archives of Biology and Technology v.56 n.2 2013
Direitos:  info:eu-repo/semantics/openAccess

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