| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Dietary models for inducing hypercholesterolemia in rats
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| Autores: |
Matos,Sheyla Leite
Paula,Heberth de
Pedrosa,Maria Lúcia
Santos,Rinaldo Cardoso dos
Oliveira,Eduardo Luiz de
Chianca Júnior,Deoclécio Alves
Silva,Marcelo Eustáquio
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| Data: |
2005-03-01
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| Ano: |
2005
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| Palavras-chave: |
Hypercholesterolemia
Animal model
Caloric value
Cholesterol
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| Resumo: |
The present work aimed at finding a dietetical model capable of promoting the highest hypercholesterolemia without affecting the development of the rats. Sixty female Fisher rats were divided into five groups. The first one was fed a control diet; the remaining four were fed hypercholesterolemic diets with cholesterol and different contents of soybean oil, starch, casein, micronutrients and fiber and, consequently, different caloric values. After eight weeks animals were evaluated in relation to growth, fecal excretion, liver weight and fat, cholesterol and its fractions, serum biochemical parameters and sistolic pressure and compared with controls. The best result was obtained with the diet containing 25 % soybean oil, 1.0 % cholesterol, 13 % fiber and 4,538.4 Kcal/Kg, since it promoted an increase in LDL-cholesterol, a decrease in the HDL fraction and affected less the hepatic function of the animals.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000200006
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132005000200006
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.48 n.2 2005
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| Direitos: |
info:eu-repo/semantics/openAccess
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