| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Inhibition of ascitic ehrlich tumor cell growth by intraperitoneal injection of Pfaffia paniculata (Brazilian ginseng) butanolic residue
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| Autores: |
Vieira,Juliana
Matsuzaki,Patricia
Nagamine,Márcia Kazumi
Haraguchi,Mitsue
Akisue,Gokithi
Gorniak,Silvana Lima
Dagli,Maria Lúcia Zaidan
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| Data: |
2010-06-01
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| Ano: |
2010
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| Palavras-chave: |
Pfaffia paniculata
Ehrlich
Intraperitoneal treatment
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| Resumo: |
This study aimed to investigate the effects of the administration of butanolic residue (BR) of Pfaffia paniculata by intraperitoneal route to Ehrlich ascitis tumor bearing mice. Initially, a toxicity study of P. paniculata BR was performed in which doses of 12.5; 25 and 50mg/Kg were administered by intraperitoneal injection for seven days to Swiss mice. The treatment did not show toxicity. Then, Swiss male mice received, by intraperitoneal injection, once a day, 12.5; 25 or 50mg/Kg of P. paniculata BR for seven days. This protocol started in the same day of tumor inoculation with 5X10(6) cells i.p. The treatment with butanolic residue of P.paniculata i.p caused a significant increase in the ascitic volume; however, a significant decrease in tumor cells number per ml (p<0.05) was observed in P. paniculata treated mice that was followed by a numerical (although non-significant) decrease in the total numbers of tumor cells in the collected ascitic fluid. These results indicated a tumor cell inhibitory effect by P. paniculata butanolic residue in this experimental system, and indicate that topical application of this residue can be useful to control the cancer growth.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000300014
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132010000300014
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.53 n.3 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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