Registro completo |
Provedor de dados: |
BJID
|
País: |
Brazil
|
Título: |
Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis
|
Autores: |
Seyyedi,Noorossadat
Dehbidi,Gholamreza Rafiei
Karimi,Mozhgan
Asgari,Amir
Esmaeili,Babak
Zare,Farahnaz
Farhadi,Ali
Dabbaghmanesh,Mohammad Hossein
Saki,Forough
Behzad-Behbahani,Abbas
|
Data: |
2019-12-01
|
Ano: |
2019
|
Palavras-chave: |
Human herpesvirus 6
Prevalence
Hashimoto disease
Autoimmune diseases
|
Resumo: |
ABSTRACT Background: Hypothyroidism due to Hashimoto's thyroiditis (HT) is the commonest autoimmune endocrine illness in which antibodies against thyroid organ result in inflammation. The disease has a complex etiology that involves genetic and environmental influences. Viral infections may be involved in triggering of the disease as their molecular mimicry enhance autoimmune responses. Human herpesvirus-6 (HHV-6) is recognized for its contribution to some autoimmune diseases. Objective: In the current study, the prevalence of HHV-6 active infection in patients with HT and with non-autoimmune thyroid disorders were compared with patients with euthyroidism. In addition, a correlation between presence of HHV-6 infections and HT was investigated. Methods: A total of 151 patients with clinically and laboratory confirmed HT, 59 patients with non-autoimmune thyroid disorders, and 32 patients with normal thyroid function were included in the study. For further confirmation of HT disease, all the precipitants were tested for anti-thyroid peroxidase (TPO), and anti-thyroglobulin (TG) antibodies. For detection of both HHV-6 types A and B, nested PCR and restriction enzyme digestion were used. HHV-6 DNA positive samples were further investigated by DNA sequencing analysis. Results: HHV-6A DNA was found in serum sample of 57 out of 151 patients (38%) with HT, which was significantly more often than in patients with non-autoimmune thyroid disorders (p = 0.001). However, HHV-6 DNA was not detected in serum samples of euthyroid subjects. Conclusions: The results support a possible role for active HHV-6A infection, demonstrated by the presence of HHV-6 DNA in sera, in the development of HT.
|
Tipo: |
Info:eu-repo/semantics/article
|
Idioma: |
Inglês
|
Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600435
|
Editor: |
Brazilian Society of Infectious Diseases
|
Relação: |
10.1016/j.bjid.2019.10.004
|
Formato: |
text/html
|
Fonte: |
Brazilian Journal of Infectious Diseases v.23 n.6 2019
|
Direitos: |
info:eu-repo/semantics/openAccess
|
|