| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Simvastatin inhibits planktonic cells and biofilms ofCandida and Cryptococcusspecies
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| Autores: |
Brilhante,Raimunda Sâmia Nogueira
Caetano,Erica Pacheco
Oliveira,Jonathas Sales de
Castelo-Branco,Débora de Souza Collares Maia
Souza,Elizabeth Ribeiro Yokobatake
Alencar,Lucas Pereira de
Cordeiro,Rossana de Aguiar
Bandeira,Tereza de Jesus Pinheiro Gomes
Sidrim,José Júlio Costa
Rocha,Marcos Fábio Gadelha
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| Data: |
2015-10-01
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| Ano: |
2015
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| Palavras-chave: |
Candida
Cryptococcus
Simvastatin
Antifungal activity
Biofilm
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| Resumo: |
ABSTRACTThe antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested againstCandida spp. and Cryptococcus spp. Then, in a second approach, considering that the best results were obtained for simvastatin, this drug was evaluated in combination with antifungal drugs against planktonic growth and tested against biofilms ofCandida spp. and Cryptococcus spp. Drug susceptibility testing was performed using the microdilution broth method, as described by the Clinical and Laboratory Standards Institute. The interaction between simvastatin and antifungals against planktonic cells was analyzed by calculating the fractional inhibitory concentration index. Regarding biofilm susceptibility, simvastatin was tested against growing biofilm and mature biofilm of one strain of each tested yeast species. Simvastatin showed inhibitory effect against Candida spp. andCryptococcus spp. with minimum inhibitory concentration values ranging from 15.6 to 1000 mg L-1 and from 62.5 to 1000 mg L-1, respectively. The combination of simvastatin with itraconazole and fluconazole showed synergism against Candidaspp. and Cryptococcus spp., while the combination of simvastatin with amphotericin B was synergistic only againstCryptococcus spp. Concerning the biofilm assays, simvastatin was able to inhibit both growing biofilm and mature biofilm ofCandida spp. and Cryptococcus spp. The present study showed that simvastatin inhibits planktonic cells and biofilms ofCandida and Cryptococcus species.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500459
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1016/j.bjid.2015.06.001
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.19 n.5 2015
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| Direitos: |
info:eu-repo/semantics/openAccess
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