| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Successful prevention of HIV transmission from mother to infant in Brazil using a multidisciplinary team approach
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| Autores: |
Nogueira,Susie A.
Abreu,Thalita
Oliveira,Ricardo
Araújo,Lúcia
Costa,Tomaz
Andrade,Miriam
Psic,M. Fátima Garcia
Machado,Elizabeth
Rodrigues,Káris
Mercadante,Elizabeth Regina
Fernandes,Iraína
Sapia,M. Conceição
Lambert,John S.
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| Data: |
2001-04-01
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| Ano: |
2001
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| Palavras-chave: |
Brazil
HIV
Prevention
Perinatal transmission
Zidovudine
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| Resumo: |
OBJECTIVES: To determine the HIV vertical transmission rate (VTR) and associated risk factors by use of zidovudine and infant care education in Brazil. METHODS: Since 1995, a prospective cohort of HIV infected pregnant women has been followed at the Federal University of Rio de Janeiro. A multidisciplinary team was established to implement the best available strategy to prevent maternal-infant HIV transmission. Patients with AIDS or low CD4 and high viral load received anti-retroviral drugs in addition to zidovudine. Children were considered infected if they had 2 positive PCR-RNA tests between 1 and 4 months of age, or were HIV antibody positive after 18 months. Education regarding infant treatment and use of formula instead of breast feeding was provided. RESULTS: Between 1995 and August, 2000, HIV status was determined for 145 infants. Compliance with intra-partum treatment, infant treatment and use of formula was 88.2%. Intra-partum zidovudine treatment was completed in 134/145 (92.6%) of patients; 88.1% had rupture of membranes < 4 hours; 85.4% of mothers were asymptomatic. The mean CD4 count was 428.4 cells and mean viral load 39,050 copies. HIV vertical transmission rate was 4/145 (2.75%; CI: 0.1%-5.4%). The only risk factor significantly associated with transmission was a failure to use zidovudine intra-partum in 2 of the 4 mothers (50% versus 6.4% in non-transmitting mothers). A trend toward low CD4 and high viral load at entry, and rupture of membranes > 4 hours were associated with increased HIV transmission. CONCLUSION: HIV vertical transmission in Brazil was reduced to a level similar to other countries with the most effective prevention programs using a multidisciplinary team approach. A high level of compliance for use of anti-retroviral drugs, the provision of health education to mothers, and use of formula for all exposed infants.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200006
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702001000200006
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.5 n.2 2001
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| Direitos: |
info:eu-repo/semantics/openAccess
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