| Registro completo |
| Provedor de dados: |
55
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| País: |
Brazil
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| Título: |
Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae
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| Autores: |
Nogueira,Keite da Silva
Daur,Alessandra Vale
Reason,Iara Taborda de Messias
Gales,Ana Cristina
Costa,Libera Maria Dalla
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| Data: |
2011-04-01
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| Ano: |
2011
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| Palavras-chave: |
Enterobacteriaceae
Beta-lactamases
Cephalosporin resistance
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| Resumo: |
The objective of this study was to evaluate the susceptibility to cefepime of a large group of ESBL- producing enterobacteria recently isolated in a Brazilian teaching hospital . The study included 280 strains of ESBL-producing enterobacteria, isolated between 2005 and 2008. The presence of the genes blaCTX-M, blaTEM and blaSHV was determined by PCR and confirmed by nucleotide sequencing. Susceptibility testing for cefepime was performed by disc-diffusion, agar dilution method and E-test®. Among the isolates, 34 (12.1%) presented a cefepime inhibition zone > 21 and MIC < 8 mg/L by agar dilution and E-strip methods. The use of cefepime for the treatment of infections caused by ESBL-producing bacteria has been controversial. Some studies of PD/PK show the probability of achieving the required PD parameters for cefepime, when the MICs were < 8 mg/L, whereas others have reported therapeutic failure with the same MIC. Additional data is essential to come to terms about the report and treatment with cefepime in ESBL-producing organisms especially when these microorganisms are isolated from sterile sites and from critically ill patients.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200014
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702011000200014
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.15 n.2 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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