| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Daptomycin and vancomycin non-susceptible methicillin-resistant Staphylococcus aureus clonal lineages from bloodstream infection in a Brazilian teaching hospital
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| Autores: |
Damasco,Andreia Paredes
Costa,Thaina Miranda da
Morgado,Priscylla Guimarães Migueres
Guimarães,Lorrayne Cardoso
Cavalcante,Fernanda Sampaio
Nouér,Simone Aranha
Santos,Kátia Regina Netto dos
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| Data: |
2019-03-01
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| Ano: |
2019
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| Palavras-chave: |
Bloodstream infection
S. aureus
Vancomycin
Daptomycin
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| Resumo: |
ABSTRACT Introduction: This study aimed to characterize Staphylococcus aureus isolates from bloodstream infections in patients attending a teaching hospital, between 2011 and 2015. Methods: The minimum inhibitory concentration for daptomycin, linezolid, oxacillin, teicoplanin, vancomycin, and trimethoprim/sulfamethoxazole was accessed by broth microdilution. SCCmec type and clonal profile were determined by molecular tests. Vancomycin heteroresistance was evaluated using screening tests and by population analysis profile/area under the curve. Results: Among 200 S. aureus isolates, 55 (27.5%) were MRSA, carrying SCCmec II (45.5%) or IV (54.5%). The most frequent MRSA lineages were USA100 (ST5-II) (45.5%) and USA800 (ST5-IV) (30.9%). Six isolates were confirmed as vancomycin heteroresistant, showing area under the curve ratio 1.1, 1.2 or 1.3 (four USA100, one USA800 and one USA1100 isolates). Conclusions: Daptomycin and vancomycin non-susceptible MRSA clonal lineages were found in bloodstream infections over five years, highlighting the importance of continuous surveillance of multiresistant bacteria in hospitals.
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| Tipo: |
Info:eu-repo/semantics/other
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200139
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1016/j.bjid.2019.03.003
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.23 n.2 2019
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| Direitos: |
info:eu-repo/semantics/openAccess
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