| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Seroprevalence of hepatitis E virus in chronic hepatitis C in Brazil
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| Autores: |
Bricks,Guilherme
Senise,Jorge Figueiredo
Pott Junior,Henrique
Grandi,Giuliano
Passarini,Amanda
Caldeira,Débora Bellini
Carnaúba Junior,Dimas
Moraes,Hamilton Antonio Bonilha de
Granato,Celso Franscisco Hernandes
Castelo,Adauto
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| Data: |
2018-03-01
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| Ano: |
2018
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| Palavras-chave: |
Hepatitis E virus
Hepatitis C virus
Brazil
Seroprevalence
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| Resumo: |
ABSTRACT Background and aims: Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality. The seroprevalence of hepatitis E virus in patients with chronic hepatitis C in Brazil is unknown. This study aims to estimate the seroprevalence of hepatitis E virus in patients with chronic hepatitis C and to describe associated risk factors. Methods: A total of 618 patients chronically infected with hepatitis C virus from three reference centers of São Paulo, Brazil were included. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA). Results: Out of the 618 patients tested, 10.2% turned out positive for anti-HEV IgG (95% CI 8.0–12.8%). Higher seroprevalence was found independently associated with age over 60 years (OR = 2.04; p = 0.02) and previous contact with pigs (OR = 1.99; p = 0.03). Conclusions: Patients with chronic hepatitis C are under risk of hepatitis E virus superinfection in São Paulo. Contact with pigs is a risk factor for the infection, suggesting a possible zoonosis with oral transmission.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200085
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1016/j.bjid.2018.02.001
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.22 n.2 2018
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| Direitos: |
info:eu-repo/semantics/openAccess
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