| Registro completo |
| Provedor de dados: |
BJID
|
| País: |
Brazil
|
| Título: |
Identification of hepatitis B virus A1762T/G1764A double mutant strain in patients in Southern Brazil
|
| Autores: |
Silva Souza,Adaliany Cecília da
Souza Marasca,Giórgia de
Kretzmann-Filho,Nélson Alexandre
Dall-Bello,Aline
Kliemann,Dimas Alexandre
Tovo,Cristiane Valle
Veiga,Ana Beatriz Gorini da
|
| Data: |
2017-10-01
|
| Ano: |
2017
|
| Palavras-chave: |
Hepatitis B
HBV
A1762T/G1764A mutation
|
| Resumo: |
Abstract Infection by hepatitis B virus (HBV) is a worldwide public health problem. Chronic HBV infection with high viral replication may lead to cirrhosis and/or hepatocellular carcinoma. Mutant HBV strains, such as the HBV A1762T/G1764A double mutant, have been associated with poor prognosis and higher risk of the patient for developing cirrhosis and/or hepatocellular carcinoma. This study analyzed the presence of the HBV A1762T/G1764A double mutant in patients with chronic HBV and its association with clinical parameters such as viral load, aminotransferases, and HBV antigens. A total of 49 patients with chronic hepatitis B were included in the study, and the HBV A1762T/G1764A double mutant strain was detected in four samples (8.16%) by polymerase chain reaction followed by restriction fragment length analysis (PCR-RFLP). The viral load was not significantly different between patients with or without the double mutant strain (p = 0.43). On the other hand, carriers of the HBV A1762T/G1764A double mutant had higher levels of ALT (p = 0.0028), while AST levels did not differ between groups (p = 0.051). In this study, 75% of the samples with the HBV A1762T/G1764A double mutation were HBeAg negative and anti-HBe positive, reflecting seroconversion even though they still displayed high viral loads. Our study has shown that the HBV A1762T/G1764A double mutant strain circulates in Brazilian patients, and is associated with elevated levels of ALT and HBeAg seroconversion.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500525
|
| Editor: |
Brazilian Society of Infectious Diseases
|
| Relação: |
10.1016/j.bjid.2017.05.002
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Journal of Infectious Diseases v.21 n.5 2017
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
