| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Detection of blaOXA-23 in Acinetobacter spp. isolated from patients of a university hospital
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| Autores: |
Corrêa,Laís Lisboa
Botelho,Larissa Alvarenga Batista
Barbosa,Lívia Carvalho
Mattos,Claudio Simões
Carballido,Jupira Miron
Castro,Carmem Lúcia Teixeira de
Mondino,Pedro Juan Jose
Paula,Geraldo Renato de
Mondino,Silvia Susana Bona de
Mendonça-Souza,Claudia Rezende Vieira de
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| Data: |
2012-12-01
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| Ano: |
2012
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| Palavras-chave: |
Acinetobacter spp
OXA-23
Carbapenem resistance
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| Resumo: |
INTRODUCTION: Acinetobacter spp. have emerged as notorious pathogens involved in healthcareassociated infections. Carbapenems are important antimicrobial agents for treating infections due to multidrug resistant Acinetobacter spp. Different mechanisms may confer resistance to these drugs in the genus, particularly production of class D carbapenemases. OXA-23-like family has been pointed out as one of the predominant carbapenamases among Acinetobacter. The present work aimed to investigate the occurrence of OXA-23-like carbapenemases among Acinetobacter isolates recovered from patients of a university hospital in Niterói, RJ, Brazil. METHODS: Antimicrobial susceptibility profiles were determined by disk-diffusion. Imipenem resistant isolates were submitted to Modified Hodge Test in order to screen for carbapenemase production, and later to polymerase chain reaction (PCR) to investigate the presence of blaOXA-23. RESULTS: Imipenem and meropenem resistance rates were 71.4% and 69.7%, respectively. The Modified Hodge Test revealed carbapenemase production among 76 (89.4%) of the 85 imipenem resistant isolates analyzed; according to PCR results, 81 isolates (95.4%) carried the blaOXA-23 gene. CONCLUSIONS: OXA-23-like enzymes may be an important mechanism of carbapenem resistance among isolates present in the hospital studied.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600004
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1016/j.bjid.2012.10.003
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.16 n.6 2012
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| Direitos: |
info:eu-repo/semantics/openAccess
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