| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Human herpesvirus-8 (HHV-8) antibodies in women from São Paulo, Brazil: association with behavioral factors and Kaposi's sarcoma
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| Autores: |
Caterino-de-Araujo,Adele
Santos-Fortuna,Elizabeth de los
Carbone,Paulo Henrique Lage
Cibella,Sandra Elisa Lopes
Moreira,Abdiel Aparecido
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| Data: |
2003-12-01
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| Ano: |
2003
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| Palavras-chave: |
Human herpesvirus - 8 (HHV-8) anti-lytic and anti-latent antibodies
HHV-8 infection in women
HHV-8 in HIV-1 infected women
HHV-8 seroprevalence
HHV-8 infection
Kaposi's sarcoma (KS)
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| Resumo: |
BACKGROUND: With the spread of AIDS, many HIV-infected women have been diagnosed with Kaposi's sarcoma (KS), especially in Africa. Since the discovery of a novel herpesvirus as the causative agent of KS (human herpesvirus 8 - HHV-8) several seroepidemiological studies have been conducted to identify groups at risk for KS. The risk for women in Brazil has not been studied. MATERIALS AND METHODS: We searched for HHV-8 antibodies in sera obtained from a bank made up of samples from 3 groups of individuals: Group I: 163 HIV-1-infected women attended at an ambulatory clinic in 1994; Group II: 108 children born to HIV-1-infected mothers from 1990 to 1992, their antibodies reflected maternal infection, and Group III: 630 HIV-1-seronegative, healthy women. In-house immunofluorescence and Western-Blot assays based on the BCBL-1 cell line were used to detect anti-latent and anti-lytic HHV-8 antibodies. RESULTS: Group I had an overall frequency of antibodies of 8.6%, with a 1.2% frequency of anti-latent antibodies and an 8.0% frequency of anti-lytic antibodies. Similar results were detected in Group II, i.e., no cases with anti-latent antibodies and a 7.4% frequency of anti-lytic antibodies. In contrast, prevalences of 1.1% anti-latent antibodies and 0.3% anti-lytic antibodies were observed in Group III. CONCLUSIONS: The epidemiologic pattern of HHV-8 in women from São Paulo varies according to behavioral factors, with emphasis on the sexual and blood routes of virus transmission/acquisition. Although HHV-8 anti-lytic antibodies were found in HIV-1-infected women, no case of KS was detected. Protective factors against KS are probably related to gender and/or to antiretroviral therapies introduced in Brazil since 1994.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600007
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702003000600007
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.7 n.6 2003
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| Direitos: |
info:eu-repo/semantics/openAccess
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