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Provedor de dados:  55
País:  Brazil
Título:  Biochemical association between essential trace elements and susceptibility to Leishmania major in BALB/c and C57BL/6 mice
Autores:  Amini,Marzyeh
Nahrevanian,Hossein
Khatami,Shohreh
Farahmand,Mahin
Mirkhani,Fatemeh
Javadian,Seifoddin
Data:  2009-04-01
Ano:  2009
Palavras-chave:  Balb/c
C57bl/6
CL
Iran
Leishmania major
Treatment
Cu
Zn
Resumo:  Several enzymes that contribute to immune system responses require zinc and copper as trace elements for their activity. We examined zinc and copper levels in two susceptible Balb/c mouse lines and resistant C57bl/6 mice infected with Leishmania major MRHO/IR/75/ER, a prevalent strain that causes cutaneous leishmaniasis in Iran. Serum Zn and Cu were determined by flame atomic absorption spectrophotometry. Higher Cu levels were found in infected C57bl/6 mice and higher Zn levels were found in infected Balb/c mice. Also, Cu/Zn ratios were increased in both the Balb/c and the C57bl/6 mice. We conclude that concentrations of essential trace elements vary during cutaneous leishmaniasis infection and that this variation is associated with susceptibility/resistance to Leishmania major in Balb/c and C57bl/6 mice. We detected Zn deficiency in the plasma of infected Balb/c mice; possibly, therapeutic administration of Zn would be useful for treating this form of leishmaniasis. Increases in Cu level might increase resistance to leishmaniasis. Based on our findings, the Cu/Zn ratio could be a useful marker for the pathophysiology of leishmaniasis.
Tipo:  Info:eu-repo/semantics/other
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200002
Editor:  Brazilian Society of Infectious Diseases
Relação:  10.1590/S1413-86702009000200002
Formato:  text/html
Fonte:  Brazilian Journal of Infectious Diseases v.13 n.2 2009
Direitos:  info:eu-repo/semantics/openAccess
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