| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis
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| Autores: |
Andrade Júnior,Dahir Ramos de
Santos,Sânia Alves dos
Castro,Isac de
Andrade,Dahir Ramos de
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| Data: |
2008-06-01
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| Ano: |
2008
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| Palavras-chave: |
TNF alpha
Tuberculosis
Cytokines
Clinical severity
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| Resumo: |
This study verified the correlation between the serum levels of TNF alpha and different clinical forms of tuberculosis. We described a group of 24 patients presenting several clinical forms of tuberculosis and a control group of 13 healthy individuals. The levels of TNF alpha were measured by bioassay method. The levels of TNF-alpha had significant differences between the tuberculosis and control groups. The patients with abnormal chest X-Ray findings had higher TNF alpha levels (15328.48 ± 4602.19 pg/mL) when compared to patients with normal X-Rays (3353.18 ± 1495.29 pg/mL) (p<0.05). Patients that lost weight had higher TNF alpha levels (15468.54 ± 4580.54 pg/mL) than those that didn't loose weight (2904.98 ± 1367.89) (p<0.05). The levels of TNF alpha were higher in patients with a positive PPD skin test than in those with a negative PPD test (p<0.05). There was a positive correlation between patients' clinical severity and the serum levels of TNF alpha. In patients with successive measurements of TNF alpha, we observed that there was a drop in cytokine levels, and also a clinical improvement concomitantly. We concluded that there was a correlation between serum TNF alpha levels and chest X-Ray alterations, loss of weight, positive PPD skin test and clinical severity in patients with tuberculosis. There was evidence of a worse clinical outcome in patients with tuberculosis that presented higher TNF alpha serum levels.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300013
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702008000300013
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.12 n.3 2008
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| Direitos: |
info:eu-repo/semantics/openAccess
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