| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
An in vivo test to assess mefloquine 25 mg/kg for the treatment of uncomplicated falciparum malaria in Rondônia, Brazil
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| Autores: |
Basano,S.A.
Bianco,A.
Taylor,W.R..J
Olliaro,P.
Camargo,L.M.A.
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| Data: |
2006-08-01
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| Ano: |
2006
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| Palavras-chave: |
Malaria
Mefloquine
Amazon
Rondônia
Therapeutics
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| Resumo: |
Drug-resistant Plasmodium falciparum is undermining malaria control efforts worldwide. In Brazil, mefloquine (MQ) at a dose of 15 mg/kg body weight is used to treat P. falciparum. At this dose, MQ resistance developed rapidly in Thailand. Use of a higher MQ dose may retard the development of resistance. We treated 50 patients aged one to 67 years who had acute, uncomplicated P falciparum malaria using MQ 25 mg/kg. There were no serious adverse events. Two patients complained of dizziness and insomnia. Assessing evaluable patients, the day 42 cure rate was 40/42 [95.2% (95% confidence interval 83.8 to 99.4%)]. Mefloquine was efficacious and well tolerated in this small cohort from the state of Rôndonia.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400013
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702006000400013
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.10 n.4 2006
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| Direitos: |
info:eu-repo/semantics/openAccess
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