| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
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| Autores: |
Angelo,Ana Luiza Dias
Angelo,Camila Dias
Torres,Alex José Leite
Ramos,André Maurício Costa
Lima,Márcia
Netto,Eduardo Martins
Brites,Carlos
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| Data: |
2007-10-01
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| Ano: |
2007
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| Palavras-chave: |
Lymphocyte counts
CD4 counts
AIDS
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| Resumo: |
This study evaluated total lymphocyte count (TLC) as a substitute marker for CD4+ cell counts to identify patients who need prophylaxis against opportunistic infection (CD4 < 200 cells/mm³) and patients with CD4 < 350 cells/mm³ (Brazilian threshold value of CD4 count to define AIDS). We evaluated TLC and CD4+ cells count of 1,174 HIV-infected patients, in Salvador, Brazil, from May 2003 to September 2004. CD4+ cell counts were performed by flow cytometry, and TLC was measured with an automated hematological counter. The mean CD4 count was 430 cells/mm³ (range: 4 to 2,531 cells/mm³). Mean TLC was 1,900 cells/mm³ (range: 300 to 6,200 cells/mm³). Using a threshold value of 1,000 cells/mm³ for TLC, the positive predictive value (PPV) was 77% for CD4 < 200 cells/mm³, but the sensitivity was only 29%, while the negative predictive value (NPV) was 88%, with 98% specificity. Similar findings were observed for CD4 count < 350. Using the same threshold value of 1,000 cells/mm³ for TLC, sensitivity was 14%, and specificity 99% (PPV= 94%; NPV=62%). In 70/1,510 (5%) of the samples the sum of CD4 and CD8 cell counts was greater than the TLC and in 27% (419/1,510) this sum was below 65% of the TLC. TLC has a high specificity to identify patients for prophylaxis, but a quite low sensitivity. It is not useful as an alternative to CD4+ T-cell counts as a marker in HIV-infected patients.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500005
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702007000500005
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.11 n.5 2007
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| Direitos: |
info:eu-repo/semantics/openAccess
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