| Registro completo |
| Provedor de dados: |
BJID
|
| País: |
Brazil
|
| Título: |
Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro
|
| Autores: |
Brilhante,Raimunda Sâmia Nogueira
Caetano,Érica Pacheco
Riello,Giovanna Barbosa
Guedes,Glaucia Morgana de Melo
Castelo-Branco,Débora de Souza Collares Maia
Fechine,Maria Auxiliadora Bezerra
Oliveira,Jonathas Sales de
Camargo,Zoilo Pires de
Mesquita,Jacó Ricarte Lima de
Monteiro,André Jalles
Cordeiro,Rossana de Aguiar
Rocha,Marcos Fábio Gadelha
Sidrim,José Júlio Costa
|
| Data: |
2016-04-01
|
| Ano: |
2016
|
| Palavras-chave: |
Histoplasma capsulatum
Saquinavir
Ritonavir
Itraconazole
|
| Resumo: |
Abstract Recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. The susceptibility assay was performed according to Clinical and Laboratory Standards Institute guidelines. All strains were inhibited by the protease inhibitor antiretroviral drugs. Saquinavir showed minimum inhibitory concentrations ranging from 0.125 to 1 μg mL−1 for both phases, and ritonavir presented minimum inhibitory concentrations ranging from 0.0312 to 4 μg mL−1and from 0.0625 to 1 μg mL−1 for filamentous and yeast phase, respectively. Concerning the antifungal itraconazole, the minimum inhibitory concentration values ranged from 0.0019 to 0.125 μg mL−1 and from 0.0039 to 0.0312 μg mL−1 for the filamentous and yeast phase, respectively. The combination of saquinavir or ritonavir with itraconazole was synergistic against H. capsulatum, with a significant reduction in the minimum inhibitory concentrations of both drugs against the strains (p < 0.05). These data show an important in vitro synergy between protease inhibitors and itraconazole against the fungus H. capsulatum.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200155
|
| Editor: |
Brazilian Society of Infectious Diseases
|
| Relação: |
10.1016/j.bjid.2015.11.003
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Journal of Infectious Diseases v.20 n.2 2016
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
