| Registro completo |
| Provedor de dados: |
BJID
|
| País: |
Brazil
|
| Título: |
Double-dose hepatitis B vaccination in cirrhotic patients on a liver transplant waiting list
|
| Autores: |
Bonazzi,Patricia R.
Bacchella,Telesforo
Freitas,Angela C.
Osaki,Karina T.
Lopes,Marta H.
Freire,Maristela P.
Machado,Marcel C.C.
Abdala,Edson
|
| Data: |
2008-08-01
|
| Ano: |
2008
|
| Palavras-chave: |
Vaccine
Cirrhotic
Hepatitis B
Liver transplant
|
| Resumo: |
Development of immunity to hepatitis B virus in cirrhotic patients waiting for liver transplantation is highly desirable. Though a double-dose regimen is available, little is know about its effectiveness. We examined the efficacy of double-dose hepatitis B virus vaccination in cirrhotic patients waiting for liver transplantation. We studied 43 patients who were waiting for liver transplantation. They were vaccinated with three doses of 40 mg hepatitis B vaccine at 0, 1 and 6 months; the normal dose is 20 mg. Efficacy was measured based on seroconversion of anti-HBs. Global response to the primary vaccination scheme was 67.5% (29 patients). Forty-one per cent of responders had anti-HBs titers above 1,000 IU/mL. No factors were associated with response, based on multivariate analysis. The vaccination scheme of 40 mg at 0, 1 and 6 months was superior to conventional vaccination doses (20 mg) for cirrhotic patients on a waiting list for liver transplantation.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400009
|
| Editor: |
Brazilian Society of Infectious Diseases
|
| Relação: |
10.1590/S1413-86702008000400009
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Journal of Infectious Diseases v.12 n.4 2008
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
