| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis
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| Autores: |
Ávila,Renata Eliane de
Carmo,Ricardo Andrade
Farah,Kátia de Paula
Teixeira,Antônio Lúcio
Coimbra,Lucas Viana
Antunes,Carlos MaurÃcio de Figueiredo
Lambertucci,José Roberto
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| Data: |
2010-08-01
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| Ano: |
2010
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| Palavras-chave: |
Liver fibrosis
Hyaluronic acid
End-stage renal disease
Haemodialysis
Hepatitis C
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| Resumo: |
BACKGROUND: This study evaluated the role of HA as a marker of liver fibrosis in patients with hepatitis C on haemodialysis. METHODS: This is a cross-sectional study in which 52 patients were divided into two groups: Group 1: patients with hepatitis C and end-stage renal disease (ESRD) undergoing haemodialysis (n = 23); and Group 2: patients with hepatitis C without ESRD (n = 29). Plasma levels of HA were associated with histological data of the samples obtained by liver biopsy and classified by METAVIR group scoring system. RESULTS: Higher plasma levels were significantly correlated to significant liver fibrosis (METAVIR > F2). In Group 1, the HA cutoff to discriminate significant fibrosis was 984.8 ng/mL, with accuracy, sensitivity and specificity of 80.8%, 83.0%, and 70.0%, respectively. In Group 2, the HA cutoff was 222.3 ng/mL, with accuracy, sensitivity and specificity of 74.5%, 70.0%, and 94.0%, respectively. CONCLUSION: HA was an accurate noninvasive marker in predicting significant fibrosis in patients with hepatitis C on haemodialysis.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400004
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702010000400004
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.14 n.4 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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