| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Klebsiella ESBL bacteremia-mortality and risk factors
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| Autores: |
Tuon,Felipe Francisco
Kruger,Margot
Terreri,Marcos
Penteado-Filho,Sergio R
Gortz,Lucas
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| Data: |
2011-12-01
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| Ano: |
2011
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| Palavras-chave: |
Klebsiella pneumoniae
Beta-lactamases
Bacteremia
Carbapenems
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| Resumo: |
Background: Extended spectrum β-lactamase (ESBL)-producing bacteria have become recognized as a problem in South America. The aim of this study was to evaluate risk factors and mortality rate in bacteremia caused by ESBL-producing Klebsiella pneumoniae in a Brazilian hospital. Methods: A three-year retrospective cohort study with 104 cases of K. pneumoniae bacteremia (61 ESBL and 43 non-ESBL). Several clinical and laboratory variables were evaluated. The outcome of interest was 30-day mortality. The adequate treatment was evaluated according to antibiotic susceptibility. Results: Multivariable analysis showed that central venous catheter and mechanical ventilation were independent risk factors for ESBL. The duration of hospitalization before the bacteremia was not a risk factor. Mortality was similar in ESBL and non-ESBL and inadequate therapy was not shown to be a risk factor. Conclusion: ESBL-producing Klebsiella bacteremia can occur early, suggesting that a carbapenem should be included in the initial empirical therapy for bacteremia in patients under mechanical ventilation and/or central venous catheter in our institution.
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| Tipo: |
Info:eu-repo/semantics/other
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600016
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702011000600016
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.15 n.6 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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