| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Combined pegylated interferon and ribavirin for the management of chronic hepatitis C in a prison setting
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| Autores: |
Sabbatani,Sergio
Giuliani,Ruggero
Manfredi,Roberto
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| Data: |
2006-08-01
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| Ano: |
2006
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| Palavras-chave: |
Chronic hepatitis C
Pegylated interferon
Ribavirin
Management
Inmates
Prison
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| Resumo: |
The elevated frequency of chronic hepatitis C virus (HCV) infection found among prison inmates, and the availability of improved pharmacological cure for this potentially life-threatening disorder, make investigations conducted in this somewhat neglected area very relevant, since only a few, open-label experiences have been reported till now. In the metropolitan prison of Bologna (Italy), HCV seroprevalence was found to be over 31% in 2003, so that a pilot feasibility study based on treatment with pegylated interferon plus ribavirin was initiated, after careful counseling carried out by a joint commission of health care personnel of the correctional facility and infectious diseases consultants. Thirty-nine patients were enrolled, and despite expected dropouts due to difficulty in maintaining the same level of counseling pressure over time, and the particularly unfavorable climatic conditions during Summer 2003, a sustained virological response was obtained for 8 out of the 21 patients who remained evaluable after the first three month follow-up, although we need to take into account that a high percentage of subjects (67%) were selected for therapy due to their favorable HCV genotypes (types 2 and 3). Our preliminary experience shows that an intrinsically complicated therapy, such as the administration of pegylated interferon plus ribavirin, can attain a relatively high success rate, even in a very unfavorable and uncomfortable context, such as a prison, where only enforced counseling, active participation of institutional health care operators, and patient's willingness to maintain an elevated level of co-operation and adherence, can overcome most structural and relational difficulties.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400012
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702006000400012
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.10 n.4 2006
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| Direitos: |
info:eu-repo/semantics/openAccess
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