| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population
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| Autores: |
Munerato,Patrícia
Azevedo,Maria Lúcia
Sucupira,Maria Cecília Araripe
Pardini,Regina
Pinto,Gedson Humberto Novaes
Catroxo,Márcia
Souza,Inara Espinelli
Diaz,Ricardo Sobhie
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| Data: |
2003-08-01
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| Ano: |
2003
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| Palavras-chave: |
CCR5
CCR2B
HIV-1 infection
Polymorphisms
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| Resumo: |
Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, although other receptors, including CCR2B and CCR3, function as minor co-receptors. A 32-nucleotide deletion (delta32) within the beta-chemokine receptor 5 gene (CCR5) has been described in subjects who remain uninfected despite extensive exposition to HIV-1. The heterozygous genotype delays disease progression. This allele is common among Caucasians, but has not been found in people of African or Asian ancestry. A more common transition involving a valine to isoleucine switch in transmembrane domain I of CCR2B (64I), with unknown functional consequences, was found to delay disease progression but not to reduce infection risk. As the Brazilian population consists of a mixture of several ethnic groups, we decided to examine the genotype frequency of these polymorphisms in this country. There were 11.5% CCR5 heterozygotes among the HIV-1 infected population and 12.5% among uninfected individuals, similar to data from North America and Western Europe. The prevalence of CCR2-64I homozygotes and heterozygotes was 0.06 and 15.2%, respectively, also similar to what is known for North America and Western Europe.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400002
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702003000400002
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.7 n.4 2003
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| Direitos: |
info:eu-repo/semantics/openAccess
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