| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Clinical and microbiological observational study on AmpC β-lactamase-producing Enterobacteriaceae in a hospital of Nepal
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| Autores: |
Baral,Pankaj
Neupanea,Sanjiv
Shresthac,Basudha
Ghimirea,Kashi Ram
Marasinia,Bishnu Prasad
Lekhaka,Binod
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| Data: |
2013-04-01
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| Ano: |
2013
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| Palavras-chave: |
AmpC β-lactamase
Enterobacteriaceae
Antibiotic resistance
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| Resumo: |
Limited information is available regarding AmpC β-lactamase (ABL)-producing Enterobacteriaceae compared to extended-spectrum β-lactamase-producing enterobacteria. Since ABL-producing organisms are often resistant to multiple antimicrobial agents, therapeutic options against these pathogens are limited. Among 230 clinical Enterobacteriaceae isolates, 64 (27.8%) were found to produce ABL in our study. Escherichia coli (83.9%) was a predominant pathogen, followed by Citrobacter freundii (5.2%). A significant proportion of ABL-producing isolates (81.3%) were found to be multidrug resistant against commonly used antibiotics. Univariate analysis showed that prior history of taking antibiotics (odds ratio [OR], 5.278; confidence interval [CI], 2.838-9.817; p < 0.001) and being inpatients (OR, 4.587; CI, 2.132-9.9; p < 0.001) were associated with ABL positivity. Regular antimicrobial resistance surveillance for ABL-producing Enterobacteriaceae is warranted for proper antimicrobial treatment strategy and policy making due to ABL-positive infections.
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| Tipo: |
Info:eu-repo/semantics/other
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200022
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1016/j.bjid.2012.09.012
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.17 n.2 2013
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| Direitos: |
info:eu-repo/semantics/openAccess
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