| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Hyponatremia, acute kidney injury, and mortality in HIV-related toxoplasmic encephalitis
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| Autores: |
Libório,Alexandre B.
Silva Jr,Geraldo B.
Silva,Carolina G.C.H.
Lima Filho,Francisco J.C.
Studart Neto,Adalberto
Okoba,Willy
Bruin,Veralice M.S. de
Araújo,Sônia M.H.A.
Daher,Elizabeth F.
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| Data: |
2012-12-01
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| Ano: |
2012
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| Palavras-chave: |
Toxoplasmosis
Encephalitis
Hyponatremia
Acute kidney injury
HIV
Mortality
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| Resumo: |
BACKGROUND: There are no reports on hyponatremia and acute kidney injury (AKI) involved in the course of HIV-related toxoplasmic encephalitis (TE). The main objective of this study was to describe the occurrence of hyponatremia and its relationship with AKI and mortality in HIV-related toxoplasmic encephalitis (TE). METHODS: This was a retrospective cohort study on patients with HIV-related TE. AKI was considered only when the RIFLE (risk, injury, failure, loss, end-stage) criterion was met, after the patient was admitted. RESULTS: A total of 92 patients were included, with a mean age of 36 ± 9 years. Hyponatremia at admission was observed in 43 patients (46.7%), with AKI developing in 25 (27.1%) patients during their hospitalization. Sulfadiazine was the treatment of choice in 81% of the cases. Death occurred in 13 cases (14.1%). Low serum sodium level correlated directly with AKI and mortality. Male gender (OR 7.89, 95% CI 1.22-50.90, p = 0.03) and hyponatremia at admission (OR 4.73, 95% CI 1.22-18.30, p = 0.02) were predictors for AKI. Independent risk factors for death were AKI (OR 8.3, 95% CI 1.4-48.2, p < 0.0001) and hyponatremia (or 9.9, 95% ci 1.2-96.3, p < 0.0001). CONCLUSION: AKI and hyponatremia are frequent in TE. Hyponatremia on admission is highly associated with AKI and mortality.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600010
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1016/j.bjid.2012.08.015
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.16 n.6 2012
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| Direitos: |
info:eu-repo/semantics/openAccess
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