| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Aminotransferase changes and acute hepatitis in patients with dengue fever: analysis of 1,585 cases
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| Autores: |
Souza,Luiz José de
Alves,José Galvão
Nogueira,Rita Maria Ribeiro
Gicovate Neto,Carlos
Bastos,Diogo Assed
Siqueira,Edno Wallace da Silva
Souto Filho,João Tadeu Damian
Cezário,Thiago de Abreu
Soares,Carlos Eduardo
Carneiro,Rodrigo da Costa
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| Data: |
2004-04-01
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| Ano: |
2004
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| Palavras-chave: |
Dengue fever
Aminotransferase
Hepatic injury
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| Resumo: |
INTRODUCTION: Type 3 dengue virus caused an extensive epidemic in the state of Rio de Janeiro in summer 2002. In some of the patients, it was found in an atypical form with increased aminotransferase levels and acute hepatitis. MATERIAL AND METHODS: An analysis was made of 1,585 serologically confirmed dengue cases at the Dengue Reference Center in Campos dos Goytacazes, Rio de Janeiro state. The grade of hepatic aggression was established according to the alterations in the aminotransferase levels: grade A - normal levels of aminotransferase; grade B - elevated aminotransferase, with increased levels of at least one of the enzymes; grade C - elevated aminotransferase, with the levels of at least one of the enzymes increased to more than three times the reference values; grade D - acute hepatitis, with aminotransferase levels increased to at least 10 times their normal values. RESULTS: Among the 1,585 serologically confirmed dengue cases, 44.5% presented alterations in the aminotransferase levels (grade B), 16.9% presented grade C liver involvement and 3.8% of the patients had progressed to acute hepatitis (grade D). The average values for the rise in aspartate aminotransferase and alanine aminotransferase were 93.3 U/L and 86.0 U/L. The greatest alterations were observed among females (p<0.001), cases of dengue hemorrhagic fever (p<0.001), and cases with sequential infections (p=0.001). CONCLUSIONS: Liver damage with elevation of aminotransferases and reactive hepatitis was a common complication of dengue virus infection in these patients.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200006
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702004000200006
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.8 n.2 2004
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| Direitos: |
info:eu-repo/semantics/openAccess
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