| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Chronic hepatitis C virus in the state of Piauí, northeastern Brazil
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| Autores: |
Veras,Kelson Nobre
Jacobina,Kelson Sousa
Soares,Vítor Y. Rocha
Avelino,Marcela Amaral
Vasconcelos,Conceição de Maria S.R.
Parente,José Miguel L.
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| Data: |
2009-04-01
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| Ano: |
2009
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| Palavras-chave: |
Epidemiology
Hepatitis C virus
Genotype distribution
Chronic hepatitis C
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| Resumo: |
Knowledge of genotype distribution of hepatitis C virus (HCV) has clinical importance due to genotype 1 lower response to treatment compared with genotypes 2 and 3. The goal of this survey was to describe clinical and laboratorial profiles of patients with chronic hepatitis C (CHC) in the State of Piauí, as well as to expand the overall awareness of the distribution of HCV genotyping in Northeast of Brazil. A retrospective cross-sectional study was carried out between April 1999 and August 2005. A total of 153 patients were included, 119 (77.8%) males and 34 (22.2%) females; mean age = 48.01 ± 9.11 years. We observed a homogeneous distribution between genotypes 1 (50.0%) and 3 (49.0%), while the most frequent subtype noticed was 3a (49.0%). The mean viral load among patients with subtype 1b (1,232,476 UI/mL) was significantly superior to the subtype 1a (391,204 UI/mL; p = 0.010) and to the subtype 3a (594,228 UI/mL; p = 0.047). The average levels of gamma-glutamiltransferase of genotype 1 (144 mg/dL) had statistical differences when compared to genotype 3 (74 mg/dL; p = 0.014). Most patients showed mild to moderate degrees of histopathological necroinflammatory activity and hepatic fibrosis (79.0% and 56.2%, respectively). We concluded that most candidates to treatment of CHC in the State of Piauí presented with clinically stable hepatic illness; the distribution of genotypes 1 and 3 was virtually homogeneous; and there was no significant demographic or clinical differences among genotypes or subtypes of HCV.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200011
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702009000200011
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.13 n.2 2009
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| Direitos: |
info:eu-repo/semantics/openAccess
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