| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America
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| Autores: |
Vidal,Jose E.
Oliveira,Augusto C. Penalva de
Dauar,Rafi F.
Boulware,David R.
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| Data: |
2013-06-01
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| Ano: |
2013
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| Palavras-chave: |
Cryptococcal meningitis
Cryptococccosis
Epidemiology
Diagnosis
Treatment
Mortality
Latin America
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| Resumo: |
Latin America is the region with the third most AIDS-related cryptococcal meningitis infections globally. Highly active antiretroviral therapy (HAART) has reduced the number of infections; however, the number of deaths and the case-fatality rate continues to be unacceptable. In this review, we focus on the burden of AIDS-related cryptococcosis in Latin America and discuss potential strategies to reduce early mortality from Cryptococcus. In this review, we highlight the importance of: (1) earlier HIV diagnosis and HAART initiation with retention-in-care to avoid AIDS; (2) pre-HAART cryptococcal antigen (CRAG) screening with preemptive fluconazole treatment; (3) better diagnostics (e.g. CRAG testing); and (4) optimal treatment with aggressive management of intracranial pressure and induction therapy with antifungal combination. Implementation of these strategies can reduce cryptococcal-related deaths, improve care, and reduce healthcare costs.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300008
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1016/j.bjid.2012.10.020
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.17 n.3 2013
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| Direitos: |
info:eu-repo/semantics/openAccess
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