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Provedor de dados:  BJMBR
País:  Brazil
Título:  Low-dose doxycycline prevents inflammatory bone resorption in rats
Autores:  Bezerra,M.M.
Data:  2002-05-01
Ano:  2002
Palavras-chave:  Tetracyclines
Bone resorption
Resumo:  Matrix metalloproteinases (MMP) are considered to be key initiators of collagen degradation, thus contributing to bone resorption in inflammatory diseases. We determined whether subantimicrobial doses of doxycycline (DX) (<=10 mg kg-1 day-1), a known MMP inhibitor, could inhibit bone resorption in an experimental periodontitis model. Thirty male Wistar rats (180-200 g) were subjected to placement of a nylon thread ligature around the maxillary molars and sacrificed after 7 days. Alveolar bone loss (ABL) was measured macroscopically in one hemiarcade and the contralateral hemiarcade was processed for histopathologic analysis. Groups of six animals each were treated with DX (2.5, 5 or 10 mg kg-1 day-1, sc, 7 days) and compared to nontreated (NT) rats. NT rats displayed significant ABL, severe mononuclear cell influx and increase in osteoclast numbers, which were significantly reduced by 5 or 10 mg kg-1 day-1 DX. These data show that DX inhibits inflammatory bone resorption in a manner that is independent of its antimicrobial properties.
Tipo:  Info:eu-repo/semantics/other
Idioma:  Inglês
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X2002000500015
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.35 n.5 2002
Direitos:  info:eu-repo/semantics/openAccess

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