| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
DNA encoding individual mycobacterial antigens protects mice against tuberculosis
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| Autores: |
Silva,C.L.
Bonato,V.L.D.
Lima,V.M.F.
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| Data: |
1999-02-01
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| Ano: |
1999
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| Palavras-chave: |
Tuberculosis
DNA vaccination
Cytokines
Th1/Th2
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| Resumo: |
Over the last few years, some of our experiments in which mycobacterial antigens were presented to the immune system as if they were viral antigens have had a significant impact on our understanding of protective immunity against tuberculosis. They have also markedly enhanced the prospects for new vaccines. We now know that individual mycobacterial protein antigens can confer protection equal to that from live BCG vaccine in mice. A critical determinant of the outcome of immunization appears to be the degree to which antigen-specific cytotoxic T cells are generated by the immune response. Our most recent studies indicate that DNA vaccination is an effective way to establish long-lasting cytotoxic T cell memory and protection against tuberculosis.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200012
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X1999000200012
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.32 n.2 1999
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| Direitos: |
info:eu-repo/semantics/openAccess
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