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Provedor de dados:  BJMBR
País:  Brazil
Título:  Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis
Autores:  Sun,F.J.
Zou,L.Y.
Tong,D.M.
Lu,X.Y.
Li,J.
Deng,C.B.
Data:  2017-01-01
Ano:  2017
Palavras-chave:  Childhood
Asthma
ADAM33
Gene polymorphisms
Asthma risk
Meta-analysis
Resumo:  This study aimed to investigate the association between ADAM metallopeptidase domain 33 (ADAM33) gene polymorphisms and the risk of childhood asthma. The relevant studies about the relationship between ADAM33 gene polymorphisms and childhood asthma were searched from electronic databases and the deadline of retrieval was May 2016. The single nucleotide polymorphisms (SNPs) of ADAM33 (rs511898, rs2280092, rs3918396, rs528557, rs2853209, rs44707, rs2280091 and rs2280089) were analyzed based on several models including the allele, codominant, recessive and dominant models. The results showed that the ADAM33 rs2280091 polymorphism in all four genetic models was associated with an increased risk of childhood asthma. Positive associations were also found between the polymorphisms rs2280090, rs2787094, rs44707 and rs528557 and childhood asthma in some genetic models. This meta-analysis suggested that ADAM33 polymorphisms rs2280091, rs2280090, rs2787094, rs44707 and rs528557 were significantly associated with a high risk of childhood asthma.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001000609
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/1414-431x20176148
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.50 n.10 2017
Direitos:  info:eu-repo/semantics/openAccess
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