Registro completo |
Provedor de dados: |
BJMBR
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País: |
Brazil
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Título: |
Antinociceptive effects of the essential oil of Croton nepetaefolius on mice
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Autores: |
Abdon,A.P.V.
Leal-Cardoso,J.H.
Coelho-de-Souza,A.N.
Morais,S.M.
Santos,C.F.
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Data: |
2002-10-01
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Ano: |
2002
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Palavras-chave: |
Croton nepetaefolius
Essential oil
Analgesic
Antinociception
Formalin test
Hot-plate test
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Resumo: |
Croton nepetaefolius Baill., is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, were evaluated in male Swiss mice (20-25 g). In the acetic acid-induced writhing test, EOCn (100 and 300 mg/kg; N = 14 and N = 12, respectively) was effective at the highest dose. In the hot-plate test, EOCn at 30 and 300 mg/kg, but not at 3 mg/kg, significantly increased the latency at all observation times up to the 180th min (N = 12 for each dose). In the formalin test, EOCn significantly reduced paw licking in the second phase of the test at 100 mg/kg (N = 12), but decreased it in both phases at 300 mg/kg (N = 12). At 30 mg/kg, the effect of EOCn did not differ from control values in either phase of the formalin test (N = 6). Pretreatment with naloxone (5 mg/kg, ip) significantly reversed the analgesic effect of morphine (5 mg/kg, sc) on both phases, but not that of EOCn at 300 mg/kg (N = 6) on both phases of the formalin test. The data show that orally administered EOCn promotes a dose-dependent antinociceptive effect whose mechanisms remain to be elucidated.
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Tipo: |
Info:eu-repo/semantics/other
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000015
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Editor: |
Associação Brasileira de Divulgação Científica
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Relação: |
10.1590/S0100-879X2002001000015
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Formato: |
text/html
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Fonte: |
Brazilian Journal of Medical and Biological Research v.35 n.10 2002
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Direitos: |
info:eu-repo/semantics/openAccess
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