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Provedor de dados:  BJMBR
País:  Brazil
Título:  Long non-coding RNA LINC00261 sensitizes human colon cancer cells to cisplatin therapy
Autores:  Wang,Z.K.
Yang,L.
Wu,L.L.
Mao,H.
Zhou,Y.H.
Zhang,P.F.
Dai,G.H.
Data:  2018-01-01
Ano:  2018
Palavras-chave:  Colon cancer
LINC00261
Β-catenin
Cisplatin resistance
Mechanism
Resumo:  Colon cancer is one of the most common digestive tumors. The present study aimed to explore the functional role, as well as the underlying mechanism of long non-coding RNA LINC00261 in colon cancer. Expression of LINC00261 was analyzed in colon cancer cell lines and human normal cell lines. Acquired resistance cell lines were then built and the acquired resistance efficiency was detected by evaluating cell viability. Thereafter, the effects of LINC00261 overexpression on cisplatin-resistant colon cancer cells were measured, as well as cell apoptosis, viability, migration, and invasion. Subsequently, we investigated the interaction of LINC00261 and β-catenin. The results showed that the LINC00261 gene was down-regulated in colon cancer cell lines and tissues, and in cisplatin-resistant cells. LINC00261 overexpression might relieve cisplatin resistance of colon cancer cells via promoting cell apoptosis, and inhibiting cell viability, migration, and invasion. Moreover, LINC00261 might down-regulate nuclear β-catenin through restraining β-catenin from cytoplasm into nuclei or it could also promote β-catenin degradation and inhibit activation of Wnt pathway. Finally, LINC00261 reduced cisplatin resistance of colon cancer in vivo and enhanced the anti-colon cancer effect of cisplatin through reducing tumor volume and weight.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200607
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/1414-431x20176793
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.51 n.2 2018
Direitos:  info:eu-repo/semantics/openAccess
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