Registro completo |
Provedor de dados: |
BJMBR
|
País: |
Brazil
|
Título: |
HLA-DR3 antigen in the resistance to idiopathic dilated cardiomyopathy
|
Autores: |
Jin,B.
Wu,B.W.
Wen,Z.C.
Shi,H.M.
Zhu,J.
|
Data: |
2016-01-01
|
Ano: |
2016
|
Palavras-chave: |
HLA-DR
Dilated cardiomyopathy
Polymorphism
Meta-analysis
|
Resumo: |
Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR3 antigen and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Studies were identified by searching the PUBMED and Embase database (starting from June 2015). A total of 19 case-control studies including 1378 cases and 10383 controls provided data on the association between HLA-DR3 antigen and genetic susceptibility to IDC. Overall, significantly decreased frequency of HLA-DR3 allele (OR=0.72; 95%CI=0.58-0.90; P=0.004) was found in patients with IDC compared with controls. When stratified by myocardial biopsy or non-biopsy cases, statistically decreased risk was found for IDC in myocardial biopsy cases (OR=0.69; 95%CI=0.57-0.84; P=0.0003). In the subgroup analysis by ethnicity, borderline statistically significantly decreased risk was found among Europeans from 12 case-control studies (OR=0.76; 95%CI=0.58-1.00; P=0.05). In conclusion, our results suggest that individuals with HLA-DR3 antigen may have a protective effect against IDC.
|
Tipo: |
Info:eu-repo/semantics/article
|
Idioma: |
Inglês
|
Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400708
|
Editor: |
Associação Brasileira de Divulgação Científica
|
Relação: |
10.1590/1414-431X20165131
|
Formato: |
text/html
|
Fonte: |
Brazilian Journal of Medical and Biological Research v.49 n.4 2016
|
Direitos: |
info:eu-repo/semantics/openAccess
|