| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
Eosinophil-active chemokines: assessment of in vivo activity
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| Autores: |
Teixeira,M.M.
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| Data: |
1998-01-01
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| Ano: |
1998
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| Palavras-chave: |
Eosinophils chemokines eotaxin MIP-1<
FONT FACE=Symbol>
A<
/font>
Chemokine receptors
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| Resumo: |
The selective recruitment of eosinophils in tissue is a striking feature of allergic diseases. Recently, a family of chemoattractant molecules, namely chemokines, has been described which potently activates eosinophil function in vitro. We have developed a murine model of eosinophil recruitment to compare the relative potency and efficacy of chemokines in vivo. Of the chemokines tested, only eotaxin and MIP-1<FONT FACE="Symbol">a</font> induced significant accumulation of eosinophils in vivo, but eotaxin was more effective than MIP-1<FONT FACE="Symbol">a</font>. Chemokines, especially eotaxin acting via the CCR-3 receptor, may have a fundamental role in determining selective eosinophil recruitment in vivo
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100003
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X1998000100003
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.31 n.1 1998
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| Direitos: |
info:eu-repo/semantics/openAccess
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