| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2)
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| Autores: |
Poli-Neto,A.
Nonoyama,K.
Oshiro,M.
Ebner-Filho,W.
Miguita,K.
Medeiros,T.M.D.
Watanabe,C.I.
Barretto,O.C.O.
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| Data: |
2000-11-01
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| Ano: |
2000
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| Palavras-chave: |
Human immunodeficiency virus
HIV1/2
Hemoglobin
Fetal hemoglobin
F cells
Zidovudine
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| Resumo: |
Fetal hemoglobin was measured in HIV1/2 patients under treatment with combined therapy (zidovudine and a protease inhibitor). A total of 143 patients and 103 normal individuals were investigated by the quantitative method of Betke and the semi-quantitative acid elution method of Kleihauer. In the normal person, hemoglobin F makes up less than 1% and an increase higher than 1.5% was observed in 21.4% of HIV patients by the method of Betke and in 24.8% of HIV-infected patients by the method of Kleihauer. The quantitative biochemical method of Betke showed that the populations were significantly different (two-tailed Mann-Whitney test). The reason for this hemoglobin F increase might be ascribed to the effect of zidovudine or to direct viral action on gamma chain expression. The finding of a higher F cell frequency indicated by the method of Kleihauer rather suggests that there is an increased F cell clone proliferation rather than an increase in hemoglobin F level in every cell.
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| Tipo: |
Info:eu-repo/semantics/other
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100008
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X2000001100008
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.33 n.11 2000
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| Direitos: |
info:eu-repo/semantics/openAccess
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